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Значение мутации n34s в гене spink1в модификации клинического течения хронического панкреатита
Автор: Ю. Кучерявый, З. Тибилова, Д. Андреев, А. СмирновЮ. Кучерявый, З. Тибилова, Д. Андреев, А. Смирнов   

 

magazine-vrach-2013-10-006

Значение мутации n34s в гене spink1в модификации клинического течения хронического панкреатита

Исследование показало, что наиболее часто мутация N34S в гене SPINK1 (панкреатический секреторный ингибитор трипсина) отмечалась у больных токсическим и идиопатическим хроническим панкреатитом (ХП). До-стоверно высокая частота идентификации указанной мутации у больных с осложненными формами идиопатического ХП предполагает повышение риска развития осложнений заболевания.
Significance of n34s mutation in the spink1gene in changing the clinical course of chronic pancreatitis
The investigation showed that the N34S mutation in the SPINK1 gene (a pancreatic secretory trypsin inhibitor gene) was most common in patients with toxic and idiopathic chronic pancreatitis (CP). The significantly high rate of identification of the above mutation in patients with complicated forms of idiopathic CP suggests the increased risk of disease complications.The investigation showed that the N34S mutation in the SPINK1 gene (a pancreatic secretory trypsin inhibitor gene) was most common in patients with toxic and idiopathic chronic pancreatitis (CP). The significantly high rate of identification of the above mutation in patients with complicated forms of idiopathic CP suggests the increased risk of disease complications.
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