Тематические порталы ИД "Русский врач": Аллергология, Гастроэнтерология, Геронтология, Гинекология, Кардиология, Педиатрия, Неврология, Травматология, Эндокринология, Эпидемиология

Конкурсы и гранты

О положительной роли ожирения в клинике внутренних болезней
Автор: Носков С., Шерина Т., Пряничникова А.   



О положительной роли ожирения в клинике внутренних болезней

В статье анализируются современные данные о влиянии ожирения на показатели смертности при заболеваниях сердечно-сосудистой системы, органов дыхания, сахарном диабете. Рассматриваются возможные причины «парадокса» ожирения и выдвигается теория особой роли мышечной системы.
The positive role of obesity in the clinical presentation of visceral diseases
The paper analyzes an update on the impact of obesity on mortality rates in cardiovascular and respiratory diseases and diabetes mellitus. It considers the possible causes of an obesity paradox and puts forth a theory of the particular role of the muscular system.


1. Abhyankar S., Leishear K., Callaghan F. et al. Lower short- and long-term mortality associated with overweight andobesity in a large cohort study of adult intensive care unit patients // Crit. Care. – 2012; 16 (6): R235.

2. Adams K., Schatzkin A., Harris T. еt al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old // N. Engl. J. Med. – 2006; 355: 763–78.

3. Angerås O., Albertsson P., Karason K. et al. Evidence for obesity paradox in patients with acute coronary syndromes: a report from the Swedish Coronary Angiography and Angioplasty Registry // Eur. Heart J. – 2013; 34 (5): 345–53.

4. Arena R., Myers J., Abella J. et al. Influence of etiology of heart failure on the obesity paradox // Am. J. Cardiol. – 2009; 104 (8): 1116–21.

5. Aursulesei V., Cozma A., Datcu M. Obesity paradox // Rev. Med. Chir. Soc. Med. Nat. Iasi. – 2009; 113 (4): 1006–15.

6. Azimi A., Charlot M., Torp-Pedersen C. et al. Moderate overweight is beneficial and severe obesitydetrimental for patients with documented atherosclerotic heart disease // Heart. – 2013 Jan 18. Epub. ahead of print.

7. Bahadori B., Uitz E., Tonninger-Bahadori K. et al. Body composition: the fat-free mass index (FFMI) and the body fat mass index (BFMI) distribution among the adult Austrian population – results of a cross-sectional pilot study // Int. J. Body Comp. Res. – 2006; 4 (3): 123–8.

8. Buettner H., Mueller C., Gick M. et al. The impact of obesity on mortality in UA/non-ST-segment elevation myocardial infarction // Eur. Heart J. – 2007; 28: 1694–701.

9. Cannon C., Kumar A. Treatment of overweight and obesity: lifestyle, pharmacologic, and surgical options // Clin. Cornerstone. – 2009; 9 (4): 55–68.

10. Cao C., Wang R., Wang J. et al. Body mass index and mortality in chronic obstructive pulmonary disease: a meta-analysis // PLoS One. – 2012; 7 (8): e43892.

11. Carnethon M., De Chavez P., Biggs M. et al. Association of weight status with mortality in adults with incident diabetes // JAMA. – 2012; 308 (6): 581–90.

12. Chang C., Chang Y., Wang M. et al. Inverse Relationship Between Central Obesity and Osteoporosis in Osteoporotic Drug Naive Elderly Females: The Tianliao Old People (TOP) Study // J. Clin. Densitom. – 2012 Jun 19. Epub. ahead of print.

13. Chrysant S., Chrysant G. New insights into the true nature of the obesity paradox and the lower cardiovascular risk // J. Am. Soc. Hypertens. – 2013; 7 (1): 85–94.

14. Cruz-Jentoft A., Baeyens J., Bauer J. et al. Sarcopenia: European consensus on definition and diagnosis // Ageand. Ageing. – 2010. doi:10.1093/ageing/afq034.

15. Curtis J., Seiter J., Wang Y. et al. The obesity paradox: body mass index and outcomes in patients with heart failure // Arch. Intern. Med. – 2005; 165: 55–61.

16. Dhoot J., Tariq S., Erande A. et al. Effect of morbid obesity on in-hospital mortality and coronary revascularization outcomes after acute myocardial infarction in the United States // Am. J. Cardiol. – 2013. doi: 10.1016.

17. Doehner W., Schenkel J., Anker S. et al. Overweight and obesity are associated with improved survival, functional outcome, and stroke recurrence after acute stroke or transient ischaemic attack: observations from the TEMPiS trial // Eur. Heart J. – 2013; 34 (4): 268–77.

18. Druml W., Metnitz B., Schaden E. et al. Impact of body mass on incidence and prognosis of acute kidney injury requiring renal replacement therapy // Int. Care Med. – 2010 Mar 16. Epub. ahead of print.

19. Fonarow G., Srikanthan P., Costanzo M. et al. ADHERE Scientific Advisory Committee and Investigators. An obesity paradox in acute heart failure: analysis of body mass index and inhospital mortality for 108,927 patients in the Acute Decompensated Heart Failure National Registry // Am. Heart J. – 2007; 153: 74–81.

20. Gallagher D., Kovera A., Clay-Williams G. et al. Weight loss in postmenopausal obesity: no adverse alterations in body composition and protein metabolism // Am. J. Physiol. Endocrinol. Metab. – 2000; 279: E124–31.

21. Gregg E., Cheng Y., Cadwell B. et al. Secular trends in cardiovascular disease risk factors according to body mass index in US adults // JAMA. – 2005; 293: 1868–74.

22. Hastie C., Padmanabhan S., Slack R. et al. Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention // Eur. Heart J. – 2010; 31 (2): 222–6.

23. Horwich T., Fonarow G., Hamilton M. et al. The relationship between obesity and mortality in patients with heart failure // J. Am. Coll. Cardiol. – 2001; 38 (3): 789–95.

24. Hsu J., Varosy P., Bao H. et al. Low body mass index but not obesity is associated with in-hospital adverse events and mortality among implantable cardioverter-defibrillator recipients: insights from the national cardiovascular data registry // J. Am. Heart Assoc. – 2012. doi: 10.1161.

25. Kahlon S., Eurich D., Padwal R. et al. Obesity and outcomes in patients hospitalized with pneumonia // Clin. Microbiol. Infect. – 2012. doi: 10.1111

26. Kang W., Jeong M., Ahn Y. et al. Obesity paradox in Korean patients undergoing primary percutaneous coronary intervention in ST-segment elevation myocardial infarction // J. Cardiol. – 2010; 55 (1): 84–91.

27. Kapoor J., Heidenreich P. Obesity and survival in patients with heart failure and preserved systolic function: a U-shaped relationship // Am. Heart J. – 2010; 159 (1): 75–80.

28. Katzmarzyk P., Mire E., Bouchard C. Abdominal obesity and mortality: The Pennington Center Longitudinal Study // Nutr. Diabetes. – 2012; 2: e42.

29. Kenchaiah S., Pocock S., Wang D. et al. Body mass index and prognosis in patients with chronic heart failure: insights from the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program // Circulation. – 2007; 116: 627–36.

30. Kim B., Lee S., Jung K. et al. Dynamics of obesity paradox after stroke, related to time from onset, age, and causes of death // Neurology. – 2012; 79 (9): 856–63.

31. Lavie C., Milani R., Ventura H. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss // J. Am. Coll. Cardiol. – 2009; 53 (21): 1925–32.

32. Lavie C., De Schutter A., Patel D. et al. Body composition and survival in stable coronary heart disease: impact of lean mass index and body fat in the «obesity paradox» // J. Am. Coll. Cardiol. – 2012; 60 (15): 1374–80.

33. Lavie C., Milani R., Ventura H. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss // J. Am. Coll. Cardiol. – 2009; 53 (21): 1925–32.

34. Lavie C., Milani R., Ventura H. Obesity and heart failure: too much of a good thing is bad? In: Clinical Challenges in Heart Failure (Vol. 1). Mehra MR (Ed.). Clinical Publishing Ltd, Oxford, UK. 2010.

35. Ma S., Park B., Yang J. et al. Interaction of body mass index and diabetes as modifiers of cardiovascularmortality in a cohort study // J. Prev. Med. Public Health. – 2012; 45 (6): 394–401.

36. McAuley P., Kokkinos P., Oliveira R. et al. Obesity paradox and cardiorespiratory fitness in 12,417 male veterans aged 40 to 70 years // Mayo Clin. Proc. – 2010; 85 (2): 115–21.

37. Miller M., Delaney C., Penna D. et al. A 3-year follow-up study of inpatients with lower limb ulcers: evidence of anobesity paradox? // J. Multidiscip. Healthc. – 2012; 5: 181–6.

38. Morse S., Gulati R., Reisin E. The obesity paradox and cardiovascular disease // Curr. Hypertens. Rep. – 2010; 12 (2): 120–6.

39. Oreopoulos A., Padwal R., Kalantar-Zadeh K. et al. Body mass index and mortality in heart failure: a meta-analysis // Am. Heart J. – 2008; 156: 13–22.

40. Oreopoulos A., McAlister F., Kalantar-Zadeh K. et al. The relationship between body mass index, treatment, and mortality in patients with established coronary artery disease: a report from APPROACH // Eur. Heart J. – 2009; 30 (21): 2584–92.

41. Persic V. Obesity in the cardiovascular continuum // Curr. Clin. Pharmacol. – 2012 Sep 3. Epub ahead of print.

42. Rolland Y., Luawers-Cances V., Pahor M. et al. Muscle strength in obese elderly women: effect of recreation physical activity in a cross-sectional study // Am. J. Clin. Nutr. – 2004; 79: 552–7.

43. Romero-Corral A., Montori V., Somers V. et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies // Lancet. – 2006; 368 (9536): 666–78.

44. Rosengren A. Declining cardiovascular mortality and increasing obesity: a paradox // CMAJ. – 2009; 181 (3–4): 127–8.

45. Shea M., Houston D., Nicklas B. et al. The effect of randomization to weight loss on total mortality in older overweight and obese adults: the ADAPT Study // J. Gerontol. A. Biol. Sci. Med. Sci. – 2010; 65 (5): 519–25.

46. Shepherd J. Is Osteoporosis an Obesity Paradox? // Clin. Densitom. – 2012 Aug 22. Epub. ahead of print.

47. Singanayagam A., Singanayagam A., Chalmers J. Obesity is associated with improved survival in community-acquired pneumonia // Eur. Respir. J. – 2012 Dec 6. Epub ahead of print.

48. Stiefelhagen P. The obesity paradox. Overweight heart patients live longer // MMW Fortschr. Med. – 2010; 152 (9): 16.

49. Trullàs J., Formiga F., Montero M. et al. Impact of weight loss on mortality in chronic heart failure: Findings from the RICA Registry // Int. J. Cardiol. – 2012. doi: 10.1016

50. Tseng C. Obesity paradox: differential effects on cancer and noncancer mortality in patients with type 2 diabetes mellitus // Atherosclerosis. – 2013; 226 (1): 186–92.

51. Uretsky S., Messerli F., Bangalore S. et al. Obesity paradox in patients with hypertension and coronary artery disease // Am. J. Med. – 2007; 120 (10): 863–70.

52. Uretsky S., Supariwala A., Singh P. et al. Impact of weight on long-term survival among patients without known coronary artery disease and a normal stress SPECT MPI // J. Nucl. Cardiol. – 2010; 17 (3): 390–7.

53. Villareal D., Apovian C., Kushner R., Kleiman S. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society // Am. J. Clin. Nutr. – 2005; 82: 923–34

54. Wang J., Zhou Y., Yuan W. Relationship between body mass index and all-cause mortality in hemodialysis patients: a meta-analysis // Zhonghua Nei Ke Za Zhi. – 2012; 51 (9): 702–7.

55. Zafrir B., Adir Y., Shehadeh W. et al. The association between obesity, mortality and filling pressures in pulmonary hypertension patients; the «obesity paradox» // Respir. Med. – 2013; 107 (1): 139–46.

56. Zajacova A., Ailshire J. Body mass trajectories and mortality among older adults: ajoint growth mixture-discrete-time survival analysis // Gerontologist. – 2013. Jan 25. Epub ahead of print.

57. Мehra M., Uber P., Park M. et al. Obesity and suppressed B-type natriuretic peptide levels in heart failure // J. Am. Coll. Cardiol. – 2004; 43 (9): 1590–5.




→ Фармакопейные статьи

→ Медицинские архивы на службе современного врача

→ Перечень медицинских технологий

ЭКД архив


Информационные партнеры: